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 Antibiotics Used in the Meat Industry Are Causing Antibiotic-Resistant Infections in Humans

  

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3,000 Americans will die this year from antibiotic-resistant infections; 80 percent of antibiotics in the U.S. are used by the meat industry. Can Big Ag and Big Pharma change in time to save this critical medicine for humans?

June 06, 2014
Richard Conniff is the author of The Species Seekers: Heroes, Fools, and the Mad Pursuit of Life on Earth and other books.
One evening in June 2011, at their home in a suburb of Portland, Ore., Melissa Lee and her husband sat down to a dinner of spaghetti and meatballs with their 10-month-old daughter. It was one of the first times Ruby Lee ever tasted meat. What followed, over the next few days, was a new parent’s nightmare of fever, diarrhea, listlessness, and doctors—culminating in an urgent phone call about blood test results: “Get Ruby to the hospital now.”


Ruby’s bloodstream was infected with a virulent bacterial strain, Salmonella Heidelberg, from the ground turkey she had eaten. She was one of 136 victims in that outbreak and among the 47.8 million cases, including 3,037 deaths, of food-borne illnesses in the United States that year. Medical detective work and DNA fingerprinting soon traced the outbreak back to Cargill, the privately owned agribusiness giant based in the Midwest, which had to recall more than 35 million pounds of ground turkey.
Ruby spent seven days in the hospital on an intravenous drip line. (The needle had to be moved from hand to foot to arm because her tiny body kept rejecting it.) Then she spent four days at home with an antibiotic line threaded into her heart. “The bacteria strain that she got, we didn’t find out till later, was antibiotic resistant,” Melissa Lee recalled not long ago. “So the fact that the antibiotic they gave her actually worked was a minor miracle.” Four other commonly prescribed antibiotics would have failed. “It was sheer luck that they gave her the right one.”

The problem for Ruby Lee and 2 million others in the U.S. who contract antibiotic-resistant infections every year is this: When antibiotics knock out unwanted bacteria, they make room for other bacteria, which are by some quirk in their genetics protected from the effect of the antibiotic. These survivors proliferate and eventually become so dominant that the drug simply has no effect on the patient. It’s natural selection, and the more antibiotics are in use, the faster it happens. The result is that important antibiotics no longer work against staph infections, urinary tract infections, gonorrhea, tuberculosis, and a growing list of other diseases. We thought we had conquered these ancient killers at the beginning of the antibiotic era (which started on D-Day, 70 years ago today), but our old enemies are back.
So after a lifetime in which a doctor could usually wipe away almost any infection simply by applying pen to prescription pad, we now stand at the brink of “a post-antibiotic era.” That’s according to an April 2014 report from the World Health Organization, and it could mean “an end to modern medicine as we know it,” Dr. Margaret Chan, director-general of WHO, recently warned. “Things as common as strep throat or a child’s scratched knee could once again kill.” In Britain, the top health official has said that antibiotic resistance threatens to become an “apocalyptic scenario,” with effects comparable to those of a catastrophic terrorist attack.
Antibiotics Used in the Meat Industry Are Causing Antibiotic-Resistant Infections in Humans
Ruby Lee was sickened by antibiotic-resistant
Salmonella in ground turkey.
(Photo: KeepAntibioticsWorking.com)
We know some of the culprits. The astonishing power of antibiotics to conquer disease made people so giddy at first that they proposed adding the drugs to canned foods, or even spraying them into the atmosphere at hospitals. Patients demanded antibiotics even when they weren’t necessarily appropriate, for a baby with an ear infection or a viral sickness. But doctors and hospitals began to see the results of misusing antibiotics almost immediately, in the form of resistant illnesses. With many old antibiotics no longer effective and no new ones coming onto the market to replace them, the medical community is now curtailing misuse of antibiotics to keep the last few lifesaving drugs effective for at least a few more years.
One large area of antibiotic misuse has hardly changed at all, however, partly because until recently no one knew just how astonishingly large it is: The single largest consumer of antibiotics worldwide since shortly after World War II isn’t the medical community at all; it’s the meat industry. The antibiotic era had just begun when researchers accidentally discovered that the addition to feed of low, or subtherapeutic, doses of antibiotics made livestock grow faster, possibly by suppressing bacteria in the gut.
From the start, researchers knew that chronic exposure to antibiotics would inevitably cause bacteria to become resistant. But the meat industry has argued that this resistance remains confined to animals and does not spill over to affect human health; the most it seems it will concede is Cargill’s statement on its website that “it is an ongoing debate about whether animal antibiotic use can adversely affect human health.” Proponents of continued livestock use also point out that antibiotics have made it possible to keep animals healthy in large-scale production facilities—enabling industry to provide cheap meat in abundance for American dinner tables. Routine use of antibiotics, and the resulting lower cost of meat, has been a significant factor in the doubling of meat consumption in this country, from just over 90 pounds per person in 1940 to 184 in the peak year of 2004. (Incidence of heart disease, stroke, type 2 diabetes, obesity, and certain cancers has spiked over the same period; medical science links all of these conditions to excessive meat consumption, which has put enormous pressure on the health care system entirely apart from the effects of antibiotic resistance itself.)
But scientific evidence about the public health risks of antibiotic use in meat production is becoming increasingly precise. That now pits much of the health care community and a broad coalition of political, social, and retail organizations against the giants that dominate the meat business—among them Cargill, Tyson Foods, ConAgra, Perdue Farms, Smithfield Foods (acquired by the Chinese firm Shuanghui International in fall 2013), and JBS S.A. (the Brazilian firm that acquired Swift + Company in 2007). Those companies account for the lion’s share of the 90-billion-plus pounds of red meat and poultry produced in the U.S. each year.

       Executives at these companies sometimes acknowledge the need to move away from some antibiotic uses, if only because of changing consumer attitudes on the issue. But antibiotics have made it possible to grow more animals faster and in more crowded conditions—the central premise of the highly concentrated modern livestock industry—so the prospect of reducing their use has little appeal. Moreover, demands for  changes that could eat into the meat industry’s bottom line come as it faces sharply increased feed costs and annual meat consumption that’s down 18 pounds per capita since 2004. (Accounting varies, but meat producers still manage to rake in well over $100 billion a year.)
The companies that supply the antibiotics—Zoetis (which spun off from Pfizer), Eli Lilly’s Elanco, and Phibro Animal Health are some of the biggest suppliers—also have little incentive to change. Selling drugs for use in livestock and companion animals has been one of the industry’s few bright spots, according to pharmaceutical analyst Steve Scala at Cowen and Company. It’s been a stable source of growth at a time when the human side of the business looks flat, with drugs becoming more expensive and difficult to develop.
But the antibiotics controversy could become a drag on that market, because cases like Ruby Lee’s are becoming disturbingly more common. Infections that resist antibiotic treatment now kill at least 23,000 Americans every year and cost the economy as much as $35 billion annually in added health care and lost productivity. Though doctors, hospitals, and patients who over- and misuse antibiotics bear some of the blame, new studies are for the first time implicating livestock antibiotics, too, and that has increased the demand for limits..............................................

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